Naturally Occurring and Biologically Active Isoxazoles

At the time of the earlier review many biologically active isoxazole and reduced isoxazole derivatives had been reported, including the naturally occurring antituberculosis antibiotic cycloserine (119), the monoamine oxidase inhibitor isocarboxazid (120), and isoxazolosteroids showing anabolic 

Christensen and P. Krogsgaard-Larsen, Acta Chem. Scand., Ser. B 32, 27 (1978). 

General Properties Radicals with Group V Ring Heteroatoms 

Department of Chemistry, University of York, Heslington, York, England 

Radicals from Pteridine, Isoalloxazine, and Related Systems.275 

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A review of isoxazole compounds (covering the period 1963—1977) discusses their synthesis, reactivity, and physiological and physicochemical properties naturally occurring and biologically active isoxazoles are included.27 Some Saudi Arabian plants have been screened for alkaloids.28 Aristolochic acids I (28 R = H) and D (28 R = OH), which are cytotoxic to mammalian systems, are also cytotoxic to non-tumorous plant cells.29... 

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