Natural product libraries from fungi

The availability of strains and an appropriate technical infrastructure are the prerequisites for the production of natural scaffolds in amounts necessary for library synthesis. For our in-house scaffold selection, we screen subfractions and compounds that originate from our own highly diverse microbial strain collection, containing more than 45,000 actinomycetes and 8,(X)0 fungi. If scaffolds are identified from literature or database mining, it may be difficult to acquire the producing strain. 

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