Natural moisturizing factor origin

The most superficial layer of skin is the stratum comeum (SC), which consists of terminally differentiated keratinocytes (comeocytes) that originate from actively proliferating keratinocytes in lower epidermis (basale, spinosum, and granulosum cells), and contain a lamellar lipid layer secreted from lamellar bodies (Fig. 7a). Flydration of the SC is an important determinant of skin appearance and physical properties, and depends on a number of factors including the external humidity, and its structure, lipid/protein composition, barrier properties, and concentration of water-retaining osmolytes (natural moisturizing factors, NMFs) including free amino acids, ions, and other small solutes. 

Oxidation is a complex process that consists of parallel bnt competing/interacting reaction processes. Although at least four such processes are believed to exist, the exact number, nature, and kinetics of such processes are not very clearly nnderstood. Althongh aerial oxidation of coal is essentially a chemical reaction process, it is inflnenced by, apart from its original chemical composition, other factors like temperature, moisture, catalytic effects of water, and components in the mineral matter. Furthermore, the effects of the physical and snrface properties play a role that is not properly understood. 

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