Nateglinide dosing

Nateglinide (Starlix) dosing is 120 mg three times daily before each meal. The dose may be lowered to 60 mg per meal in patients who are near goal A1C when therapy is initiated. 

Monotherapy and combination with metformin or a thiazolidinedioneiThe recommended starting and maintenance dose of nateglinide, alone or in combination with metformin, is 120 mg 3 times/day before meals. 

Absorption - Following oral administration immediately prior to a meal, nateglinide is rapidly absorbed with mean peak plasma drug concentrations (Cmax) generally occurring within 1 hour (T ax) f er dosing. Absolute... 

Gribble FM, Manley SE, Levy JC. Randomized dose ranging study of the reduction of fasting and postprandial glucose in type 2 diabetes by nateglinide (A-4166). Diabetes Care 2001 24(7) 1221-5. 

NATEGLINIDE, REPAGLINIDE ISONIAZID 1 efficacy of antidiabetic drugs Isoniazid causes hyperglycaemia, the mechanism being uncertain at present Monitor capillary blood glucose closely t doses of antidiabetic drugs may be needed... 

In a randomised, double-blind study, 11 healthy subjects were given nateglinide 120 mg three times daily for 5 days, with a single 10-mg dose of acenocoumarol on day 3. Nateglinide had no effect on the tolerability, pharmacokinetics or anticoagulant activity of acenocoumarol. ... 

In another study,12 healthy subjects were given nateglinide 120 mg three times daily for 4 days with a single 30-mg dose of warfarin on day 2. No pharmacokinetic or pharmacodynamic interaction was noted. No dosage adjustments would therefore be expected to be necessary if nateglinide is taken with either acenocoumarol or warfarin. 

In contrast, in a very similar study by the same research group, the combination of gemfibrozil and itraconazole caused only a modest 47% increase in the AUC of a single dose of nateglinide 30 mg, and did not significantly alter the blood glucose response to nateglinide in healthy subjects. ... 

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