Narcotic analgesics concepts

Portoghese PS. A new concept on the mode of interaction of narcotic analgesics with receptors. J Med Chem 1965 8 609-616. 

Leading concepts of the nature of the analgesic receptor, as well as pertinent stereochemical studies of narcotic analgesics, have been reviewed by Portoghese. Differing modes of drug-receptor association and the phenomenon of Induced fit are favored as possible explanations for some of the complexities that characterize structure-activity relationships In this field. 

---