Nanoxynol suppository with bacterial culture

Scale (mg/suppository) Item Material Name Quantity/1000 Suppositories (g) 

The benzalkonium chloride or methylbenzetho-ninm chloride, imidiazolidinyl urea, and diazo-lidinyl urea are added slowly, while thoroughly stirring, to a suspension of hydroxypropyl methyl cellulose and microcrystalline cellulose in a sterile normal saline solution (quantity sufficient to a make a thick paste) at 35°-37°C. 

The pH is slowly lowered to about 6.0-6.3 with reagent grade lactic acid. (This step binds the antimicrobials to the cellulose excipients.) 

The suspension is stirred for 2 hours, and then ascorbic acid that was dissolved in about 10-15 mL sterile saline is slowly added with gentle stirring. 

The material is, at this point, a very thick paste. 

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