Nanotechnology oral bioavailability

Not withstanding the use of nanoparticles for intravenous and topical applications, improvement in oral bioavailability is one of the most important contributions attained through nanotechnology. Molecules that are poorly water soluble may be poorly absorbed because of a lack of sufficient concentrations of solubilized drug. Formulations that are amorphous can overcome this by supersaturation of the dissolution medium allowing for greater absorption of the delivered dose. However, stability problems are significant for... 

The occnrrence of a mucus layer that present at the surface of various organs has been exploited to develop mucoadhesive dosage forms. These layers act as administration site to prolong time, and increase the local and/or systemic bioavailability of the administered drug [58]. The appearance of micro and nanotechnologies simultaneously with the execution of non-invasive and painless administration routes has transforms the pharmaceutical market and the management of disease. Intending to minimize the chief limitations of the oral route and... 

---