Nano-hybrid Consisting of Hydroxyapatite and Protein

Laminine-containing metastable calcium phosphate solution 

Bioactive ceramics have already played an important role in bone repair in the clinical fields because of their ability to bond to living bone. However, the use of these bioactive ceramics is limited because of their brittleness and higher Young s modulus than bone. The combination of ceramic and organic components provides us with a design for novel tissue-repairing materials. The establishment of these techniques promises a novel bone repairing material. 

1 Hench, L.L., Splinter, R.J., Allen, W.C. and Greenlee, T.K. Jr. (1971) Bonding mechanism at interface of ceramic prosthetic materials. Journal of Biomedical Materials Research Symposium, 2, 117-141. 

2 Hench, L.L. (1991) Bioceramics from concept to clinic. Journal of the American Ceramic Society, 74, 1487-1510. 

3 Jarcho, M., Kay, J.L., Gumaer, R.H. and Drobeck, H.P. (1977) Tissue, cellular, and subcellular events at a bone-ceramic apatite interface. Journal of Bioengineering, 1, 79-92. 

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