Insomnia naltrexone

Naltrexone is hepatotoxic and contraindicated in patients with hepatitis or liver failure. LFTs should be monitored monthly for the first 3 months, then every 3 months. Side effects include nausea, headache, dizziness, nervousness, insomnia, and somnolence. 

Nausea is the most common side effect of naltrexone, occurring in about 10% of patients. Other side effects are headache, dizziness, nervousness, fatigue, insomnia, vomiting, anxiety, and somnolence. 

Opiates Pupillary constriction, constipation, drowsiness, coma, slurred speech, respiratory depression, Flu-like muscle aches, nausea or vomiting, yawning, piloerection, [animation, rhinorrhea, fever, insomnia, pupillary dilation Opiates receptors, locus cereleus pathway (noradrenergic) Naloxone (short half-life), naltrexone (longer half-life), donidine (ease withdrawal), methadone, LAMM (Levo-ac-aretyl-methadol) substitute addictions,longer withdrawal period Males > Females 3 1 TB, AIDS, hepatitis, pulmonary hypertension, pneumonia... 

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