Naloxone pharmacological properties

The pharmacological properties of the cloned opiate receptors are similar to the characteristics of the endogenously expressed receptors [9, 36, 45]. The binding of opiates to the cloned receptors is stereoselective and the antagonist naloxone interacts with all three of the cloned receptors, although naloxone had much lower af-... 

Naltrexone and nalmefene are structurally related to naloxone. Naltrexone is the /V-cyclopropy I methyl analogue of oxymorphone while nalmefene is the /V-allyl analogue. They have similar pharmacological properties to naloxone but with longer durations of action, with elimination half-lives in excess of 8 hours. They also have significant oral availability. They are used mainly in the management of addicts. 

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