Nalidixic, Pipemidic, and Oxolonic Acids

D. Nalidixic, Pipemidic, and Oxolonic Acids I. Physicochemical and Pharmacologic Properties... [Pg.533]

Nalidixic, Pipemidic and Oxolonic Acid-Speciflc Antibodies... [Pg.536]

Brehm and Korting (1970) had a positive consumption test with cutis extract, but consumption tests with epidermis, vessels, and thymic nuclei were negative. The consumption test by Steffen demonstrates incomplete antibodies. Therefore there is evidence that the bullous nalidixic acid reaction of the skin is an allergic phenomenon with incomplete antibodies against cutis. Routine demonstration of antibodies against nalidixic, pipemidic, and oxolonic acids are not usual. [Pg.536]

Routine lymphocyte transformation tests for nalidixic, pipemidic, and oxolonic acids are not usual, but may be helpful if more than one potential sensitizing medicament has been given. The clinical impression that phototoxic reactions to nalidixic acid are not related to specific antibodies is supported by negative lymphocyte transformation tests (Alexander and Forman 1971). [Pg.536]

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