Nalidixic, Pipemidic, and Oxolonic Acid-Specific Lymphocyte Reactions

Nalidixic, Pipemidic and Oxolonic Acid-Specific Lymphocyte Reactions 

Brehm et al. (1970) demonstrated fluorescence in the stratum granulosum by means of immunofluorescent examination of a skin biopsy in a patient with bullous reaction of the skin after nalidixic acid. 

Routine lymphocyte transformation tests for nalidixic, pipemidic, and oxolonic acids are not usual, but may be helpful if more than one potential sensitizing medicament has been given. The clinical impression that phototoxic reactions to nalidixic acid are not related to specific antibodies is supported by negative lymphocyte transformation tests (Alexander and Forman 1971). 

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