Nalidixic acid Warfarin

Nalidixic Acid Nalidixic acid should not be given with nitrofurantoin or mel-phalan. It interacts with cyclosporin, probenecid, and warfarin. [Pg.335]

Leor J, Levartowsky D, Sharon C. Interaction between nalidixic acid and warfarin. Arm Intern Med 1987 107(4) 601. [Pg.998]

Sellers EM, Koch-Weser J. Displacement of warfarin from human albumin by diazoxide and ethacrynic, mefenamic, and nalidixic acids. Clin Pharmacol Ther 1970 ll(4) 524-9. [Pg.1277]

Nalidixic acid can displace warfarin from its plasma albumin binding sites, briefly enhancing its anticoagulant effect (32). [Pg.2419]

Warfarin + nalidixic acid Possible hypolbrombinaemia with associated haemorrhage risk Displacement from protein (NB In vitro evidence) Combination administration should be used with care and patient coagulation monitored... [Pg.429]

Most studies show that the quinolones have, at most, a small, clinically insigniilcant effect on the pharmacokinetics and pharmacodynamics of warfarin. Despite this, increased effects and even bleeding have been seen quite unpredictably in isolated cases in patients taking warfarin with ciprofloxacin, gatifloxacin, levo-floxacin, moxifloxacin, nalidixic acid, norfloxacin or ofloxacin or while taking acenocoumarol when given nalidixic acid, norfloxacin or pefloxacin, or phenprocoumon with norfloxacin. Fur-... [Pg.373]

A patient stabilised on warfarin (prothrombin ratio 2), developed a purpuric rash and bruising within 6 days of starting nalidixic acid 500 mg four times daily. Her prothrombin ratio had risen to 3.46. Another patient, previously well controlled on warfarin, developed a prothrombin time of 60 seconds 10 days after starting nalidixic acid 1 g three times daily.The INR of an 84-year-old woman taking warfarin rose from 1.9 to 9.6 when nalidixic acid was added. Similarly, a patient taking acenocoumarol developed hypoprothrombinaemia after receiving nalidixic acid 1 g daily. ... [Pg.374]

Class 2 (High PermeabiUty, Low Solrrbility) Azathioprine, Azithromycin, Alprazolam, Warfarin, Haloperidol, Glipizide, Griseofulvinum, Danazol, Dapsone, Diclofenac, Indometacin, Itraconzol, Carbamazepine, Carvedilol, Ketoconazole, Lansoprazol, Mebendazole, Mefloqrrine, Nalidixic acid. Nevirapine, Piroxicam, Praziquantel, Ritonavir, Rifampicinirm, Spironolactone, Tamoxifen, Terfenadine, Trimethoprim, Ibnprofen, lopanoic add, Lovastatin, Naproxen, Oxaprozin, Flubiprofen, Cisapride. ... [Pg.480]

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