Naive T-cells

Fig.1. Differentiation ofT cells content of micromilieu and several cytokines and other cofactors released from DCs are essential for the differentiation of naive T cells into T-helper(Th)l,Th2,Th9,Thl7 effectorT-cell subsets. 

Ngo VN, Tang HL, Cyster JG. Epstein-Barr virus-induced molecule 1 ligand chemokine is expressed by dendritic cells in lymphoid tissues and strongly attracts naive T cells and activated B cells. J Exp Med 1998 188(1) 181—191. 

Weninger W, Carlsen HS, Goodarzi M, et al. Naive T cell recruitment to nonlymphoid tissues a role for endothelium-expressed CC chemokine ligand 21 in autoimmune disease and lymphoid neogenesis. J Immunol 2003 170(9) 4638-4648. 

Hirata H, Arima M, Cheng G, et al. Production of TARC and MDC by naive T cells in asthmatic padents. J Clin Immunol 2003 23(l) 34-45. 

Finally, it has been shown that maturation of DCs is promoted by metabolized ginsenosides such as compound K. Takei et al (2004) showed that mature DCs differentiated with compound K enhance the differentiation of naive T cells toward the Thl t) e depending on lL-12 secretion, which clearly suggests that compound K has immunostimulatoty effects and that this compound is involved in the cancer preventive effects of ginseng and that compound K may be used on DC-based vaccines for cancer immunotherapy (Takei et al, 2004). 

L, Marinos N, McGrady G, Wahl SM Conversion of peripheral CD4+CD25— naive T cells to CD4+CD25+ regulatory T cells by TGF-(J induction of transcription factor Foxp3. J Exp Med 2003 198 1875-1886. 

The initial event responsible for the development of allergic diseases is the generation of allergen-specific CD4-F T-helper (Th) cells. The current view is that under the influence of IL-4, naive T cells activated by antigen-presenting cells differentiate into Th2 cells [34-36]. Once generated, effector Th2 cells produce IL-4, IL-5 and IL-13, and... 

Dendritic cells (DCs) were originally described by their capacity to efficiently process and present antigens and to prime naive T cells [1]. Over the last three decades, multiple DC sub-types have been defined, differing in phenotype, localization and immune function [2]. In the most general view, immature DCs are situated in the periphery at sites of antigen exposure. Here,... 

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