NADP nicotinamide adenine dinucleotide oxidase

The resulting oxidized LDL particles trapped in the vessel wall can undergo a number of other reactions including lipolysis, proteolysis and aggregation, which contribute to inflammation and foam cell formation. A multitude of oxidation pathways have been proposed that involve 12/15-lipoxygenase, metals ions, myeloperoxidase producing hypochlorous acid, and NADP (nicotinamide adenine dinucleotide phosphate) oxidase. 

Exchange of the nicotinamide moiety of NADP for nicotinic acid, forming NAADP. Early studies also showed that the enzyme can catalyze exchange of nicotinamide with a variety of other bases, including histamine. Formation of histamine adenine dinucleotide phosphate was thought to provide an alternative to amine oxidase for rapid inactivation of histamine. 

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