N-tosyl-L-alanine

C11H14CIN03S N-tosyl L-alanine chtoromethyl ketone 31982-00-0 379.20 32.410 1,2 22138 C11H1402 3-tert-butyl-2-hydroxybenzaldehyde 24623-65-2 480.16 41.981 2... 

In the case when the compound reacting with the optically active molecule also possesses one or more electronic transitions the evidence of the chemical interaction can become indiscutable. The very existence of an association submits the electronic transitions of the compound to the dissymmetry of the chiral molecule. They become optically active and, consequently, detectable by the intermediary of the corresponding induced COTTON effects. Figure 9 shows the induction of optical activity in the d-d transition of the Cuii ion complexed with the optically active ligand N-tosyl L-alanine(YI) in aqueous solution at pH 10 [18]. 

The lower rim C-linked AT-tosyl peptidocalix[4]arenes [78] of type 60 bearing l- or D-amino acid residues were prepared and studied for their anion recognition ability. The H NMR titrations proved that in all cases only the 1 1 complexes are formed in CDC13 with high complexation constants (e.g. 60,d,l-Ala, n=4, R=Pr K60 (HSO )=3,850 M"1, K60 (AT-tosyl-L-alaninate)=6,900 M-1). 

However, the following suggested method can be used a reference curve can be obtained by measuring the pKo values of N-tosyl L-a-alanine, chosen as a model for PLL, in various acetone-water mixtures. The pK values of PLL in these mixtures can... 

Inhib. abbrev. DTT = dithioghreitol E64D = epoxysuccinyl-L-leucyl-amido-3-methyl-butane ethyl ester EDTA = ethylene-diamine-tetra-acetic acid EGTA = ethylen-glycol-tetra-acetic acid LHVS = morpholinurea-leucine-homophenyl-alanine-vinylsulfone-phenyl NEM = N-ethyl-maleimide PAI = plasminogen activator inhib. PMSF = phenil-methyl-sulfonil fluoride SBTl = soybean trypsin inhib. TIMP = tissue inhib. of metalloproteinases TPCK = tosyl-L-phenyl-alanyl-chloro-methane Al.so termed stephins. 

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