N-Sulfinyl Thio urea Catalysts

1 (a) Hof, K., lippert, K.M., and SAreiner, P.R. (2012) in Science of Synthesis. Asymmetric Organocatalysis 2. Bronsted Base and Acid Catalysis and Additional Topics (ecL K. Maruoka), Thieme Stuttgart, New York, pp. 297-412 (b) Schreiner, P.R. (2003) 

12 Wittkopp, A. (1998) Wasserstojfhruckenhindungen als dirigierende Wechselwirkung in der organischen Synthese Thioharnstojfe als Katalysatoren, Diploma thesis. University of Gottingen. 

Calvet, T., Font-Bardia, M., Moyano, A., and Rios, R. (2012) Org. Eiomol. Chem., 10, 431. 

35 Raimondi, W., Lettieri, G., Dulcere, J.-P., Bonne, D., and Rodriguez, J. (2010) Chem. Commun., 72A7. 

New applications demanded changes in catalyst structure. The steric bulk around the sulfur atom was increased and a tertiary amine function was introduced on a cyclohexyl framework in catalyst 37 to efficiently promote the addition reactions ofthioacetic acid to nitroalkenes [139]. The general procedure developed here was applied as the key asymmetric step in the synthesis of (R)-sulconazole (32% overall yield for five steps, 96% ee). A very similar catalyst was used in the 

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N-sulfinyl (thio)urea catalysts 335 N-sulfinyl ureas 1029 sulfinylation 1256 sulfonamides 335 -aryl 1299... 

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