N-Substituted Norpethidines

Table 5.3. ANALGESIC ACTIVITIES OF SOME N-SUBSTITUTED NORPETHIDINES AND CORRESPONDING REVERSED ESTERS...

Table 6.1. Relative Analgesic Activities of N-Substituted Norpethidines in Ratsa...

Janssen and Eddy(41) have given a semiquantitative estimate of the influence of systematic chemical modifications on analgesic potency in mice and rats of a series of N-substituted norpethidines and reversed esters of pethidine. Their estimates, based on the results of the hot-plate test obtained in three separate laboratories, are illustrated in Scheme 6.3. 

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