N-oxidation, of trimethylamine

This enzyme system catalyzes the oxidation of various nitrogen-, sulfur -, and phosphorus-containing compounds, which tend to be nucleophilic, although compounds with an anionic group are not substrates. For example, the N-oxidation of trimethylamine (Fig. 4.19) is catalyzed by this enzyme, but also the hydroxylation of secondary amines, imines, and arylamines and the oxidation of hydroxylamines and hydrazines ... 

Mannich reagent. French chemists reported that use of trifluoroacetic anhydride rather than acetic anhydride in the Polonovski reaction resulted in improved yields (2, 7, 8). They1 now find that the reaction of trifluoroacetic anhydride with the N-oxide of trimethylamine leads to the trifluoroacetate of N,N-dimethylformaldimmonium (1). This ion is considered to be the actual reagent in... 

Al-Waiz M, Ayesh R, Mitchell SC, Idle JR, Smith RL. A genetic polymorphism of the N-oxidation of trimethylamine in humans. Clin Pharmacol Therap 1987 42 588-594. 

Substitution of CO ligands in clusters is most commonly realized in the same way as in the case of mononuclear metal carbonyls. Substitution may be induced by one of the following, most frequently utilized methods thermal, electrochemical, chemical (reactions with N-oxide of trimethylamine or Bu"PO), photochemical, catalysis by radicals, catalysis by transition metal compounds, etc. ... 

---

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

---