N-Nitrosodimethyl amine

Ohshima, H. Kawabata, T. Mechanism of N-nitrosodimethyl-amine formation from trimethyl amine and trimethylaminoxide. In Walker, E. A. Castegnaro, M. Griciute, L. Lyle, R. E., Eds. "Environmental Aspects of N-Nitroso Compounds" lARC Scientific Publication No. 19 International Agency for Research on Cancer Lyon, France, 1978 pp. 143-153. 

NMOR = N-nitrosomorpholine, NDMA = N-nitrosodimethyl amine, NDPhA = N-nitrosodiphenyl amine... 

Gui L, Gillham RW, Odziemkowski MS. Reduction of N-nitrosodimethyl-amine with granular iron and nickel-enhanced iron. 1. Pathways and kinetics. Environ Sci Technol 2000 34 3489-3494. 

Naphthol N-nitroso 1-naphthol (1 mole) and N-nitrosodimethyl amine... 

Spiegelhalder, B., Eisenbrand, G., and Preussmann, R., 1979, Contamination of beer with trace quantities of N-nitrosodimethyl-amine. Food Cosmet. Toxicol. 17 29. 

Cigarette smoke is known to contain N-nitrosodimethyl-amine. Someone smoking a pack of cigarettes a day inhales about 0.8 fig of N-nitrosodimethylamine, and even more has been shown to be present in the sidestream smoke. 

Very little information is available on the uptake of N-nitrosoamine from soils by plants. Uptake of W-nitrosodimethyl-amine and N-nitrosodiethyl amine from soil by wheat, barley and... 

Aliphatic and aromatic amines react with nitrous acid to form N-nitroso derivatives. For example, dimethylamine hydrochloride on treatment with sodium nitrite and hydrochloric acid is converted to nitrosodimethyl amine in 90% yield. In like manner, N-nitrosomethylaniline is synthesized from N-methylaniline in 93% yield. The ready formation of these derivatives and the easy reconversion to the amine by reduction affords an advantageous procedure for separating secondary amines from primary and tertiary amines, as shown in the synthesis of N-ethyl-m-toluidine and other N-alkyl derivatives by the alkylation of w-toluidine. ... 

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