N-Heterocyclic Carbenes as Asymmetric Organocatalysts

Beijing National Laboratory for Molecular Sciences, Key Laboratoiy of Molecular Recognition of Function, Institute of Chemistiy, Chinese Academy of Sciences, Beijing 100190, China Email songye iccas.ac.cn 

Sustainable Catal3fsis Without Metals or Other Endangered Elements, Part 2 

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Marion N, Diez-Gonzalez S, Nolan SP (2007) N- Ielcrocyclic carbenes as organocatalysts. Angew Chem Int Ed 46 2988-3000 Matsumoto Y, Tomioka K (2006) C2 symmetric chiral /V-heterocyclic carbene catalyst for asymmetric intramolecular Stetter reaction. Tetrahedron Lett 47 5843-5848... 

Over the past decade, rapid growth has been achieved in organocatalytic asymmetric Diels-Alder and hetero-Diels-Alder reactions. Numerous organocatalysts such as chiral amines, guanidines, N-heterocyclic carbenes, Bronsted acids, and bifunctional catalysts have been successfully developed. The activation modes for these catalysts, such as imine-catalysis, enamine-catalysis, dienamine catalysis. 

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