N,Dimethylation

Vilsmeier reagent The reagent obtained from POCI3 mixed with either N,N-dimethyl-formamide or N-methylformanilide. Used for introducing the methanoyl (formyl) (-CHO) group into activated aromatic substrates. 

Figure B2.4.1 illustrates this type of behaviour. If there is no rotation about the bond joining the N, N -dimethyl group to the ring, the proton NMR signals of the two methyl groups will have different chemical shifts. If the rotation were very fast, then the two methyl enviromnents would be exchanged very quickly and only a single, average, methyl peak would appear in the proton NMR spectrum. Between these two extremes, spectra like those in figure B2.4.1 are observed. At low temperature, when the rate is slow, two...

The influence of a large number of oc-amino acids on the values of and k at have been determined. These a-amino acids included glycine, L-valine, L-leucine, L-phenylalanine, L-tyrosine, L-tryptophan, NOrmethyl-L-tryptophan (L-abrine), N-methyl-L-tyrosine, N,N-dimethyl-L-tyrosine and p -me thoxy-N-me thyl -L -phenyl al anine. 

Because coupling is not always quantitative, the non-reacted terminal deoxynucteoside must be excluded from the following synthesis cycles. Otherwise deletion sequences will render the isolation of the pure final product difficult. Therefore a capping step (step 3) follows, e.g., acetylation with acetic anhydride and N,N-dimethyl-4-pyridinamine (DMAP) in dioxane. Capping times should be as short as possible, especially with 2-cyanoethyl phosphite triesters, which are sensitive to bases such as DMAP. 

Aza-8-germaspiro-[4,5]-decane-2-propanamine-8,8-diethyl-N,N-dimethyl dihydrochloride... 

AMNES - AMINES,AROMATIC - PHENYLENEDIAMINES] (Vol 2) N,N-Dimethyl-p-phenylenediamine [99-98-9]... 

N,N- dimethyl- aceto acetamide [2044-64-6] bp 75-77 (0.2 kPa) insecticides, polyester curing... 

N- (methoxymethyl)-methacr5i amide N- (dimethyl amino-ethy1)methacry1-amid e... 

Condensation of phenol [108-95-2] C H O, withy -nitroso-N,N-dimethyl-aniline [138-89-6] CgH QN20, in acetic acid (9). 

The hydrolysis of 2- and 4/6-alkylthiopyrimidines to the corresponding pyrimi-dinones is best done in hot acidic media (within a fume hood). For example, N,N-dimethyl-2-methylthiopyrimidin-4-amine (365) in boiling 6M hydrochloric acid gives... 

H NMR, 4, 557, 566 <75CS(7)21I) Furan-2-carboxamide dipole moment, 4, 555 [Pg.24]

A -1,3,4-Oxadiazoline-5-thione H NMR, 6, 428 (72CJC3079) A -l,3,4-Oxadiazolin-5-imine, 4,N-dimethyl-2-phenyl-... 

Tellurophene-2-carboxamide, JV, N-dimethyl-PE, 4, 25 <76JCS(P2)276> Tellurophene-2-carboxylic acid... 

Acetamide, af,Q, Q -trifluoro-N,N-dimethyl-trifluoromethyl ketones from, 4, 833-834... 

Pyrimidin-4-amine, N, N-dimethyl-2-methylthio-demethylation, 3, 95 Pyrimidin-4-amine, 5-ethoxy methyl-... 

Pyrrole-2-carboxamide, N,N-dimethyl-conformation, 4, 194 Pyrrole-3-carboxamide, N,N-dimethyl-conformation, 4, 194 Pyrrolecarboxamides synthesis, 4, 242 Pyrrole-2-carboxamides synthesis, 4, 148, 360 Pyrrolecarboxylhydrazides Curtius degradation, 4, 362 Pyrrole-2-carboxylic acid, l-benzyl-3-hydroxy-ethyl ester... 

Pyrrolo[3,2-6]pyrrole, N,N -dimethyl-UV spectra, 4, 1044 Pyrrolo[3,2-6]pyrrole, octahydro-synthesis, 4, 1081 Pyrrolopyrroles H NMR, 4, 1041 occurrence, 4, 1042 reactivity, 4, 1049 synthesis, 4, 1068 Pyrrolo[2,3-6]pyrroles ionization potentials, 4, 1046 synthesis, 4, 293, 1070 Pyrrolo[3,2-6]pyrroles synthesis, 6, 1009 Pyrrolo[3,2-6]pyrroles, dihydrosynthesis, 4, 1081 Pyrrolo[3,4-c]pyrroles applications, 4, 1083 Pyrroloquinolines... 

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