N- -2-aminofluoren

Boche and co-worker ° carried out detailed studies of the decomposition reactions of various A -hydroxylamine esters in the presence of DNA and deoxygua-nosine, and characterized the adducts that resulted from these reactions. Thus, the nitrenium ion derived from 0-acetyl-N-(2-aminofluorene) added to DNA to give an adduct joining the C8 position of the base with the nitrenium ion nitrogen. Similar experiments carried out with the precursor of 2-naphthylnitrenium ion gave N2-ortho 148 and C8-N adducts 149 as shown in Figure 13.72. ... 

Mekhovich, O., Tang, M., and Romano, LJ. (1998) Rate of incision of N-acetyl-2-aminofluorene and N-2-aminofluorene adducts by UvrABC nuclease is... 

Bichara, M., and Fuchs, R. P. P. (1985). Binding and mutation spectra of the carcinogen N-2-aminofluorene. A correladon between the conformation of the premuta-genic lesion and the mutation specificity. / Mol. BioL 183, 341-351. 

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