N- acylamid

The controlled photoelectrochemical oxidation of imides presents an interesting example of chemoselectivity. The photoinduced oxidation of lactams to imides, Eq. (22) and of N-acylamides to imides, Eq. (23) introduces oxygen into the organic substrate, but if the reaction is conducted in the presence of Cu(I), unsaturation is induced instead, Eq. (24)... 

The Negative Ionizable feature was augmented to map on N-acylamides (0=C-NH-C=0) motif such as in Quis (Fig. 15.6a). 

Much faster reaction can be achieved with strong bases (/07). The chain is started by an N-acylimide which may be N-caproyl-caprolactam produced in a slow reaction from the monomer during an induction period or an N-acylamid produced by action of a cocatalyst like for example carboxylic acid chlorides or anhydrides on caprolactam. The cocatalyst action speeds up the reaction such, that fast polymerization below the melting point of the polymer becomes possible. The strong base, such as alkali metal, metal hydride, metal amid, or oiganometallic compound, activates the monomer by lactam anion formation ... 

N-(Acoxy)acylamines N-Acylamide acetals 1 -Acylamino-l-peroxides Acyl hydroxamates Acylurethans Carbamic carboxylic anhydrides... 

N-Acylamide acetals Acyl hydroxamates Acylurethans Carbamic carboxylic anhydrides... 

The mechanism of photo-oxidative degradation of polyamides has also been investigated using low molecular weight compounds such as JV-hexyl-hexanamide 1,6-hexamethylenebis(hexanamide) iV,JV -bis(hexyl)adipamide N-alkylamides and N-acylamides [587, 1221, 1348, 1683, 1880, 1959]. 

The 1-substituted imidazoles ozonolysis leads to the formation of the corresponding N-acylamides, which are important amine or acyl derivatives [94],... 

Jancso, N. Desensitization with capsaicin and related acylamides as a tool for studying the function of pain receptors, edited by K. Lin, D. Armstrong, E.G. Prado, Pharmacology of Pain, 1968, Pergamon Press, Oxford, 33-55. 

Phosphor(III)-chlorid reagiert mit N-Alkoxymethyl-N-N -dialkyl-harnstoffen zu cycli-schen Phosphonsaure-acylamid-chloriden225 z.B. ... 

Dithiophosphorsaure-acylamid-S,S-dicstcr sind nach folgenden Methoden zuganglich CO Umsetzung von Dithiophosphorsaure-chlorid-S,S-diestem mitNatrium-phthalimid in polaren Losungsmitteln (z.B. Dimethylformamid, N-Mcthyl-pyrrolidon)822 ... 

Alkalimetall-acylamide (z.B. Kalium-phthalimid) werden in polaren Losungsmitteln (N-Methyl-pyrrolidon) mit Thiophosphorsaure-chlorid-0,0-diestem zu Thiophosphor-saure-acylamid-0,0-diestern (—50%) umgesetzt413. Mit 1-Methyl-imidazol als Ka-talysator erhohen sich die Ausbeuten z.B. Thiophosphorsiiure-0,0-diethylester-phthalimid (-85% Schmp. 81-83°)414 ... 

Thiophosphorsaure-acylamid-amid-O-ester sind nach folgenden Methoden zuganglich 1. Umsetzung von Thiophosphorsaure-amid-chlorid-O-estern z.B. mit Kalium-phthal-imid in N-Methyl-2-pyrrolidon544,545 ... 

Triprotection of the 12-16-membered tetraazacycles was also achieved through organometallic approaches. Chromium(O) or molybdenum(O) tricarbonyl triamino complexes (e.g., 163-165) <1995JOM215> are substituted with acylhalogenides or aldehydes and N-monosubstituted products are obtained after oxidative deprotection in strong acid and acylamide/enamine reduction to amines <1995TL79>. 

Figure 6-6. Commercially available chambers for acylamide gel electrophoresis of short and long gels. Arrows in the left apparatus point to the platinum electrode wires. (Courtesy of Savant Instruments, Inc., Hicksville, N.Y.)...

In compounds which have no substituents at N-l or N-2 nuclear acylation also occurs and under some conditions acylation occurs at C-4. The use of 2-alkyl- or aryl-5-imino-3-pyrazolidinones, which exist as the 3-amino-2-pyrazolin-5-one isomer, with an equivalent of acid chloride, either aliphatic or aryl, leads to 3-acylamides (eq. 266),14,67,594,695,1247,1594,1595 although in some cases a side-reaction gives both N- and O-acylation.1595 Under the same conditions 3-hydroxy-5-imino-2-pyrazolinones give O-acylation.1599 The reaction of... 

The soluble and stable IBX analogues having pseudo-benziodoxazine structure, N-(2-iodylphenyl)acylamides 499, have been prepared in good yields by the oxidation of 2-iodoaniline derivatives 498 with 3,3-dimethyldioxirane under mild conditions (Scheme 2.142) [663]. X-Ray data on compounds 499 revealed a unique pseudo-benziodoxazine structure with an intramolecular secondary I - O... 

N-Acylation. A soln. of aniline, bis-(0-adipoyl) cyclohexanone oxime and acetic acid in chloroform warmed 3 hrs. at 60° adipanilide. Y 97%.—The acylketoximes are stable to heat and such solvents as water and alcohol, permitting acylations in a variety of suitable solvents. F. e. s. Y. V. Mitin, T. Y. Stolyarova, and G. P. Vlasov, 33, 3628 (1963) G. A. 60, 7951h also acylamid-oximes as acylating agents cf. R. Buyle, Helv. 47, 2444 (1964). 

O. Kirino, K. Furuzawa, C. Takayama, H. Matsumoto, and A. Mine, /. Pesticide Sci. Nippon Noyaku Gakkaishi), 8, 301 (1983). Quantitative Structure-Activity Relationships of the Herbicidal N-(l-Methyl-l-phenylethyl)acylamides. 

Kobata K., Saito K., Tate H., Nashimoto A., Okuda H., Takemura L, Ken M., Takahashi M., Iwai K., Watanabe T. Long-chain N-VaniUyl-acylamides from Capsicum oleoresin. Journal of Agricultural and Food Chemistry, 58 3627-3631 (2010). 

When the probe polymer is smaller than the network size, the diffusion behavior of the probe molecule can be expressed by Eq. (22) in a similar manner as for a spherical particle. In this case, the fluid dynamic radius IJj, is used in place of the size of the particle R. Several researchers measured the diffiision coefficient of poly(ethylene glycol) (PEG) in a poly(N,N-dimethyl-acylamide) gel swollen to the equilibrium state by heavy water using the (PGSE)- H NMR technique. They obtained the relationship between the degree of swelling q and the PEG diffiision coefficient Dp Q (see Fig. 12) [19, 20]. 

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