N-acyl phosphatidylethanolamine

Shangguan T, Cabral-Lilly D, Purandare U, et al. A novel N-acyl phosphatidylethanolamine-containing delivery vehicle for spermine-condensed plasmid DNA. Gene Ther 2000 7(9) 769-783. 

Burstein and Hunter (1995) observed that THC stimulated the biosynthesis of anandamide in neuroblastoma cells employing either ethanolamine or arachidonic acid as the label. Anandamide bios5mthesis has also been shown to occur in primary cultures of rat brain neurons labelled with [H]-ethanolamine when stimulated with ionomycin, a Ca ionophore (Di Marzo et al. 1994). These authors proposed an alternate model for the biosynthesis of anandamide in which N-arachidonoyl phosphatidyl ethanolamine is cleaved by a phospholipase D activity to yield phosphatidic acid and ararchidonoylethanolamide. This model is based upon extensive studies undertaken by Schmid and collaborators (1990), who have shown that fatty acid ethanolamide formation results from the N-acylation of phosphatidyl ethanolamine by a transacylase to form N-acyl phosphatidylethanolamine. Possibly resulting from postmortem changes, this compound is subsequently hydrolyzed to the fatty acid ethanolamide and the corresponding phosphatide by a phosphodiesterase, phospholipase D. 

Domingo, J. C. Rosell, K Mora, M. De Madariaga, M. A. Importance of the puriflcation grade of 5(6)-carboxyfluorescein on the stability and permeability properties of N-acyl-phosphatidylethanolamine liposomes. Biochem. Soc. Trans. 1989,17,997-999. 

Reddy, P.V., Schmid, PC., Natarajan, V., Muramatsu, T., Schmid, H.H.O., 1984. Properties of canine myocardial phosphatidylethanolamine N-acyl transferase. Biochim. Biophys. Acta 795, 130-136. 

CH2CH2NH3 Phosphatidylethanolamine Widespread and major lipid. N-Acyl... 

Phospholipids can be separated from other polar lipids by normal-phase LC. Thus, on isocratic elution with acetonitrile-methanol-sulfuric acid (135 5 0.2), phosphatidylinositol elutes first followed by monogalactosyldiacylglycerol, N-acylphosphatidyle-thanolamine, N-acyl-lysophosphatidylethanolamine, phosphatidylethanolamine, and digalactosyldiacyl-glycerols. 

Abbreviations PC, phosphatidylcholine PE, acyl phosphatidylethanolamine. phosphatidylethanolamine PI phosphatidylinositol NAPE, N-... 

Renin inhibitors have been found among naturally occurring phospholipids and synthetic phosphatidylethanolamine derivatives. Pepstatin (5.131), isolated from Streptomyces strains, is a pentapeptide with an acylated N-terminus and the unusual 4-amino-3-hydroxy-6-methylheptanoic acid (AHMH) residues. It is a general protease... 

Docosahexaenoic acid (DHA, 22 6n-3) is the most abundant polyunsaturated fatty acid (PUFA) acylated to the aminophospholipids phosphatidylethanolamine (PE) and phosphatidylserine (PS) in membranes of neurons within the central nervous system (CNS) (Naughton, 1981 Salem et al., 1986). It can occur in concentrations exceeding 30-mol% of the fatty acids (Salem, 1989). The high enrichment ofDHA in synaptosomes is especially striking and suggests that DHA has unique properties that are required for optimal neuronal function. This concentration in the CNS is even more remarkable when one considers that sources of n-3 fatty acids are disproportionately limited in the terrestrial food chain compared to the much more abundant n-6 fatty acids. 

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