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Myoinositol-1,4,5-triphosphate

The synthesis of 3-0-aIkylated (Me, Et, Pr) myoinositol 1,4,5-triphosphate as potent receptor ligands and enzyme inhibitors and of 3-amino-3-deoxy-myo-inositol 1,4,5-triphosphate as a pH dependent partial antagonist at the myoinositol 1,4,5-trisphosphate receptor of neuroblastoma cells have been described. [Pg.245]

The preparation of 5-methylphosphonate and 5-(difluoromethyl)phosphonate analoguesof myoinositol 1,4,5-triphosphate and 1,3,4,5-tetraphosphate has been disclosed. Other phosphonate derivatives to have been synthesized include D,L-myo-inositol 1,4,5-trimethylphosphonate, 43-bis and 5-mono methyl phosphonates. ... [Pg.206]

Neuronal and hormonal signals may often be transduced via receptor-mediated activation of phophoinositidase C (inositol lipid-directed phospholipase C), which converts phosphatidyl-inositol 4,5-bisphosphate (PIP2) to 1,2-diacyl-glycerol (1,2 DG) and D-inositol 1,4,5-triphosphate [(1,4,5)IP3] in the cell membrane. These metabolic products are second messengers 1,2 DG stimulates protein kinase C and (1,4,5)IP3 releases intracellular calcium from the endoplasmic reticulum. Subsequently, (1,4,5)IP3 is ultimately converted to myoinositol. That in turn is converted to phosphatidylinositol, which is used to replenish PIP2 stores and thus complete the cycle. ... [Pg.19]

The pH optimum for hydrolysis by the major acid phosphatase (EC 3.1.3.2) associated with the aleurone particle of rice grains Oryza sativa Japonica cv. Koshihikari) was 4.8 (Yamagata et al., 1980). The values were respectively 1.74 mM for para-nitrophenyl phosphate and 5.26 mM for adenosine triphosphate. They decreased slightly with an increase in the number of phosphate groups of various inositol phosphates, being 0.43 and 11.76 mM for myoinositol hexakisphosphate and myo-inositol monophosphate, respectively. In addition, the 17 values for myo-inositol bis- and tri-sphosphate were high (564-611 pmol phos-phate/min/mg protein). [Pg.94]

Myoinositol is a naturally occurring vitamin with a hexahydroxycyclohexane structure its phosphorylated forms are readily converted to trimethylsilyl derivatives which, as has been observed for alkyl ethoxy phosphates, can be separated by SFC at temperatures some hundreds of degrees below those necessary for GC of such compounds [14]. Both silylated inositol triphosphate and phytic acid (inositol hexaphosphate) were eluted... [Pg.291]

The synthesis of myo-inositol 1,4,5-triphosphate has been achieved from myoinositol derivatives by formation of D-mannose orthoester derivatives. [Pg.217]


See other pages where Myoinositol-1,4,5-triphosphate is mentioned: [Pg.425]    [Pg.257]    [Pg.96]    [Pg.97]    [Pg.102]    [Pg.143]    [Pg.425]    [Pg.507]    [Pg.257]    [Pg.169]    [Pg.96]    [Pg.97]    [Pg.102]    [Pg.295]   
See also in sourсe #XX -- [ Pg.3 , Pg.257 ]

See also in sourсe #XX -- [ Pg.216 , Pg.218 ]

See also in sourсe #XX -- [ Pg.97 , Pg.102 ]




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