Myogen nature

Myopathies have been described in several sporadic cases with lactic acidosis, cytochrome oxidase (COX)-positive RRF in muscle, and isolated complex I deficiency, and have been attributed to various pathogenic mutations in ND genes. The sporadic nature of these myopathies suggests that the ND mutations are de novo, arising spontaneously in myogenic stem cells after germ-layer differentiation (somatic mutations) [14]. 

Under these conditions, naturally myogenic cells, such as skeletal myoblasts, cardiocytes, or any progenitor cell driven down a muscle lineage appear the logical first choice. However, the ultimate proof of any cell superiority will require side-by-side comparisons of cells in similar disease state studies, which to date are limited or nonexistent. 

Regulation of CBF is a complex dynamical process and remains relatively constant over a wide range of perfusion pressure via a variety of feedback control mechanisms, such as metabolic, myogenic, and neurally mediated changes in cerebrovascular impedance respond to changes in perfusion pressure. The contribution to the overall CBF regulation by different areas of the brain is modeled by the statistics of the fractional derivative parameter, which determines the multifractal nature of the time series. The source of the multifractality is over and above that produced by the cardiovascular system. 

Controversy has existed over the line of cellular differentiation in alveolar soft part sarcoma (ASPS) ever since its seminal description in 1952. Despite attempts to prove a neuroectodermal or endocrine nature for this tumor, more recent studies have endorsed a myogenous phenotype. 

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