Myeloid Neoplasia

The t(9 22)(q34 qll) translocation with its cytogenetic appearance as Philadelphia chromosome was the first demonstrated chromosome rearrangement in neoplasia. This translocation is the hallmark of the chronic myeloid leukemia nevertheless it is also found in association with other hematological malignancies such as acute... 

Kao HW, Sanada M, Liang DC, Lai CL, Lee EH, Kuo MC, Lin TL, Shib YS, Wu JH, Huang CF, Ogawa S, Shih LY. A high occurrence of acquisition and/or expansion of C-CBL mutant clones in the progression of high-risk myelodysplastic syndrome to acute myeloid leukemia Neoplasia 2011 13 1035 2. 

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