Myeloid enzyme: FucT

The myeloid enzyme, FucT IV, is also known as ELAM-1 ligand fucosyltransferase (ELFT) [7, 43, 44]. The human FucT IV is located on chromosome llq21 and is expressed in cells of the myeloid lineage. 

Figure 10. Cooperative action of a3-NeuAcT (a3-ST, dashed arrow), a3-FucT IV (myeloid enzyme a3-FT, thin solid arrow), and a3-FucT VII (a3-FT, leukocyte enzyme bold solid arrow) in the synthesis of sialyl-oligomeric Lewis and related structures on polylactosaminoglycan chains. F, Fuc G, Gal GN, GlcNAc LAG, polylactosaminoglycan SA, NeuAc.

Within the a3/4-fucosyltransferase family six different members have been identified. They are numbered in the order they were cloned FucT III-VII and IX. Human FucT III (Lewis enzyme), V and VI (hver/plasma enzyme) are highly related enzymes with >90% identity at the amino acid level in their catalytic domain their genes are all located on human chromosome 19 [135]. By contrast, FucT IV (myeloid enzyme, chromosome 11) and FucT VII (leukocyte enzyme, chromosome 9) have a more distal relationship to each other and to the other members of this family [135, 136]. Recently a novel member, FucT IX, which has highest homology to FucT rv, was cloned from a mouse library [137]. Recently the human ortholog of FucT IX was described [138]. 

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