Myeloid bodies aminoglycosides

The morphological alterations induced by aminoglycosides in LLC-PKi cells correlated well with in vivo histological findings in the kidney, including the formation of secondary lysosomal inclusions referred to as myeloid bodies. 

Figure 29.10. Postulated pathways of aminoglycoside-induced cellular injury. On the left, aminoglycoside (AG) enters the cell by pinocytosis and endocytosis, subsequently fusing with a primary lysosome (L). Aminoglycosides may interfere with normal lysosomal function, forming myeloid bodies (center). Additionally, aminoglycosides may destabilize lysosomes, leading to release of intralysosomal enzymes (lower left). Intracellular aminoglycosides may produce direct injury to intracellular organelles such as mitochondria. (Adapted from G.J. Kaloyanides and E. Pastoriza-Munoz, Kidney Int. 18, 571-582,1980.)...

Aminoglycoside binding to membrane acidic phospholipids Changes in content and metabolism of membrane phospholipids Displacement of calcium bound to phospholipids Formation of myeloid bodies... 

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