Mycelia sterilia

Figure 7 Structures of related cyclooctadepsipeptides from Mycelia sterilia. PF1022A is the main product in Mycelia sterilia. PF1022A, R3 = R3 = benzyl, R2 = R, = methyl PF1022B, R, R2 R, R-4 = benzyl PF1022C, R, R2 = R, = benzyl, R, = methyl PF1022D, R, = benzyl, R2 = R3 = R, = methyl PF1022E, R, = benzyl, R2 = R, = methyl, R3 = />-hydroxybenzyl PF1022F, R, = R2 = R3 = R, = methyl bassianolide, Ri = R2 = R3 = Rt = isopropyl PF1022-202, R, R, methyl, R2 = R = />-hydroxy-benzyl.

W Weckwerth. Studies on the biosynthesis of cyclooctadepsipeptides from Mycelia sterilia. Ph.D. thesis, Technische Universitat Berlin, Berlin, 1998. 

W Wcckwerth, G House, H Kleinkauf, R Zocher. Purification and characterization of D-2-hydroxyphenyllactate dehydrogenase from Mycelia sterilia. In preparation. 

A novel depsipeptide PF1022A, isolated from a Mycelia sterilia, represents a promising new class of potent anthelmintics [356]. Compound (222) consists of eight residues, four N-methyl-L-leucines, two D-lactates and two 3-phenyl-D-lactates, elaborating a floppy 24-membered ring. In motility assays, it showed potent activity towards Heterakis spumosa (10 7 g/ml) [361] and H.contortus (0.1 pM) [357]. It appears however that it acts as a neurotoxin by paralysing the nematode [358] and its activity is... 

Bacillus Dactyltum Mycelia Sterilia Pseudomonas Trichothecium... 

Class Fungi Imperfecti Order Mycelia Sterilia Common Name White Mold. 

Macroscopic Appearance Typicalfy appearing as a fast growing whitish mycelium, fine and or cottony in its growth. Species of Mycelia Sterilia closely resemble mushroom mycelium and may be mistaken for it. Sometimes they form whitish to blackish aggregates of hyphae that are sclerotia-like. 

Comments Mycelia Sterilia is often called a "garbage order" for non-sporulating mycelium of molds that can not be otherwise identified. Either a fungus has lost the ability to produce spores and can exist only in a vegetative state, or it will only produce spores on media of narrow nutritional specifications. In both cases, it is extremely difficult, if not impossible, to identify a fungus that has no visible conidial (sporulating) stage. 

Class Fungi Imperfecti Order Mycelia Sterilia Common Name Brown Plaster Mold. Latin Root From papulosus meaning pimple-like and spora or spore. Named in reference to the rounded groups of cells that resemble sclerotia and are characteristic of this genus. 

Because no conidial (spore producing) phase is known, it has been placed in the "garbage" order of little understood fungi, the Mycelia Sterilia. 

Imperf. - Monlllales) (Imperf. - Mycelia Sterilia) (Schlzo. - Eubacteriales)... 

Homoallylic, /hh, and allylic couplings, Vhh, have been used by Gao et to elucidate the structure of (4i , 5S, 65, 85, 137 )-1-(2,8-dihydroxy- 1,2.6-trimethyl-1,2,6,7,8,8a-hexahydro-naphtalen-1 -yl)-3-meth-oxy-propan-l-one, a polyketide-originated metabolite isolated from a marine sponge-derived fungus Mycelia sterilia. 

Agonomycetes. Also known as Mycelia Sterilia. Lacking spores, they are not strictly speaking mitosporic, but are included with mitosporic fungi for convenience. Some have morphological features such as sclerotia or traps for eelworms that facilitate identification. 

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