Heterakis spumosa

The enniatins are a group of cyclodepsipeptides produced by Fusarium spp [206]. They are produced by a non-ribosomal mechanism and their biosynthesis is regulated by the amino acids of the metabolic pool [354], Enniatin A (220) (5 pg/ml) showed nematocidal activity towards N. brasiliensis, Trichinella spiralia and Heterakis spumosa, and other enniatins were active at 1-100 (ig/ml [355]. Enniatin B (221) (100 (ig/ml) was toxic towards Anguillula aceti [142] and M. javanica (LD43 20 ppm) [233]. 

A novel depsipeptide PF1022A, isolated from a Mycelia sterilia, represents a promising new class of potent anthelmintics [356]. Compound (222) consists of eight residues, four N-methyl-L-leucines, two D-lactates and two 3-phenyl-D-lactates, elaborating a floppy 24-membered ring. In motility assays, it showed potent activity towards Heterakis spumosa (10 7 g/ml) [361] and H.contortus (0.1 pM) [357]. It appears however that it acts as a neurotoxin by paralysing the nematode [358] and its activity is... 

Ascaridia galli, 37°C Ascaris lumbricoides, large, 37°C A. lumbricoides, small, 37°C A. lumbricoides (male), 37°C A. lumbricoides (female), 37°C Heterakis spumosa, 38°C Litomosoides carinii, 37.5°C... 

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See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ ]

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