Myalgias docetaxel

Docetaxel -semisynthetic taxane stabilizes tubulin polymers leading to death of mitotic cells -bone marrow suppression -nausea and vomiting -mucocutaneous effects (mucositis, stomatitis, diarrhea) -hypersensitivity reactions -fluid retention syndrome -fatigue -myalgias -alopecia (universal)... 

DOCETAXEL DOXORUBICIN t plasma concentrations of docetaxel (t AUC by 50-70%) with t efficacy and also t risk of toxicity, particularly when docetaxel is administered after doxorubicin, compared with administration of docetaxel alone Uncertain possibly due to interference with hepatic microsomal enzymes Monitor closely for T incidence of bone marrow suppression, neurotoxicity, myalgia and fatigue... 

Docetaxel Nausea and vomiting hypersensitivity reactions Bone marrow depression fluid retention peripheral neuropathy alopecia arthralgias myalgias cardiac coxiciiy mild Gl disturbances mucositis... 

Metabolism/elimination Hepatic metabolism Adverse reactions Alopeda, nausea/vomiting/diarrhea, myelosuppression (dose-limiting, granulocytopenia, and thrombocytopenia), hepatic toxidty, peripheral neuropathy, hypersensitivity reactions, myalgias/arthralgias, rare cardiovascular events, fluid retention/pulmonary edema (docetaxel). 

Musculoskeletal Docetaxel is associated with arthralgias and myalgias, usually starting 1-2 days after infusion and lasting up to 5 days [142 ]. As with paclitaxel, gaba-pentin given prophylactically controls symptoms in some patients [69 ]. 

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