Muticomponent reaction

The reactions of thiourea and guanidine with cycloalkanones are carried out in the same manner [101]. But it is worthwhile noting that muticomponent reactions of urea-like compounds with ketones, containing an activated methyl or methyle-negroup, often do not stop after the formation of a pyrimidine ring. In fact numerous derived condensation processes can lead to more complicated polycyclic compounds, which are especially typical for the reaction of cycloalkanones [101]. 

Groenendaal B, Rujiter E, Orru RVA. 1-Azadienes in cycloaddition and muticomponent reactions towards N-hetero-cycles. Chem. Common. 2008 5474-5489. 

Another attractive field of research in combination with muticomponent polymerizations is that of photochemical reactions. The modular nature of MCRs allows the simple introduction of photoresponsive moieties, offering novel and extremely versatile reaction or modification possibilities. For instance, the Passerini addition polymerization of adipic acid, 1,6-diisocyanohexane, and photosensitive 2-nitrobenzaldehyde led to poly(ester-amide)s with photolabile linkages in the backbone (Scheme 6) [43]. UV-irradiation (2 = 365 nm) of the polymer solution... 

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