Suppressor mutation

SUMOl (Small Ubiquitin-like modifier 1) Sentrin SMT3C (suppressor of MIF2 mutations 3) GMP1 (GAP-Modifiying Protein 1) Ubll (Ubiquitin-like protein 1) PIC1 (PML interacting protein 1)... 

Suppressor Mutations Can Counteract Some of the Effects of Missense,... 

Adenomatous polyposis coli (APC) gene A tumor suppressor gene, acting as a gatekeeper to prevent development of tumors. A familial cancer syndrome called FAP, or familial adenomatous polyposis, is caused by mutations in APC. Mutation of APC also occurs commonly in sporadic cases of colorectal carcinoma. 

Tumor suppressor genes Genes that normally restrain cell growth, but when missing or inactivated by mutation, allow cells to grow uncontrolled and tumors to form. 

Moore, K. J., Swing, D. A., Rinchik, E. M., Mucenski, M. L., Buchberg, A. M., Copeland, N, G., and Jenkins, N. A. (1988). The murine dilute suppressor gene dsu suppresses the coat color phenotype of three pigment mutations that alter melanocyte morphology, d, ash, and In. Genetics 119 933-941. 

Nonsense mutations change normal codons into nonsense codons. In viruses, nonsense mutations are recognized because hosts are available that contain suppressors able to read nonsense codons. The virus mutant will be able to grow in the host containing the suppressor, but not in the normal host. 

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