Mutations antigen-antibody interfaces

Fig. 4. Solvent rearrangement in an antigen-antibody interface induced by a mutation in the antigen. (A) Schematic representation of the FvD1.3-HEL Asp-18 —4 Ala complex in the vicinity of the mutation. (B) Schematic showing the same region in the wild-type FvD1.3-HEL complex. Water molecules present in both structures are labeled WAT 1-4. WATa, WATb, and WATc are additional waters in the FvD1.3-HEL Asp-18 Ala interface.

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