Mutation-induction kinetics mathematical analysis

In this chapter, we have set forth a formal mathematical description of mutation-induction kinetics on the basis of certain simplifying assumptions. The resulting equations are sufficient for the analysis of many dose-response relationships found for radiations and chemicals. From this base, more elaborate mathematical methods could be developed to deal with more complex experimental situations or macromolecular processes than we have considered here. 

Another important area of research is the modification of mutagenic activity. In the chapter by Sugimura and Nagao, factors that alter in vitro metabolic activation are discussed, whereas in the chapter by Maher and McCormick, the role of genetic heterogeneity is considered. Equally important is our need to obtain a better understanding of mutation-induction kinetics, and the mathematical analysis by Haynes and Eckardt provides an important step in this direction. An important new approach for the induction of specific locus mutations in human cells in culture is discussed in the chapter by Thilly and co-workers. 

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