Mutagenesis in mammals

E. Vogel and G. Rohrbom, eds.. Chemical Mutagenesis in Mammals and Man, Spriuger-Vedag, Berlin, 1970. 

L. Schoeller and V. Wolf in "Chemical Mutagenesis in Mammals and Man," F. Vogel and G. Rohrborn, Eds., Springer-Verlag, New York, 1970,... 

The influence of transposons and insertion elements in basic mutagenesis is just beginning to be understood, and it is not known how pervasive or important transposition is in mammals. This is a very active field, and we expect that important results will be available soon. 

Russell, L.B. Numerical sex-chromosome anomalies in mammals Their spontaneous occurrence and use in mutagenesis studies, pp. 55-91. In A. Hollaender,... 

Chemical mutagenesis in laboratory mammals A bibliography on the effects of chemicals on germ cells (EMIC report)... 

Niida H, Nakanishi M. DNA damage checkpoints in mammals. Mutagenesis 2006 21 3-9. 

The principal pathway by which unsubstituted and many substituted aromatic hydrocarbons are metabolized in mammals consists of the initial formation of arene oxides, which undergo a variety of enzymatic and nonenzymatic reactions prior to excretion of the resulting more polar, oxidized hydrocarbons via bile or urine. Taken together, these pathways represent an attempt on the part of the animal to detoxify or eliminate such nonpolar xenobiotic substances for which it has no apparent use. Although detoxification is the probable role of the arene oxide pathway, it is equally clear that chemically reactive species mediate this process. Thus, studies over the past several years have either implicated or established arene oxides in a causative role in such adverse biological reactions as cytotoxicity, mutagenesis, and carcinogenesis via covalent interaction of arene oxides with biopolymers,... 

The two purple adenine genes, ad-3A and ad-3B, are closely linked. By using a forced heterokaryon heterozygous for the ad-3 A and the ad-3B locus, Webber and de Serres were able to show that X-ray-induced specific-locus mutations in the ad-3 region were either point mutations or chromosome deletions (Webber and de Serres, 1965). The same classes of mutations are picked up in the specific-locus system in mice (Russell, 1951,1967). To sunmiarize in de Serres purple adenine system we have a eukaryotic, microbial assay system in which the same type of mutations can be isolated as in mammals. However, because it is a microbial system, it is considerably easier to perform quantitative mutagenesis studies with this system than with mice. 

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