Muscle, skeletal intramuscular drug administration

Intramuscular. The large quantity of skeletal muscle in the body allows this route to be an easily accessible site for parenteral administration. Intramuscular injections can be used to treat a problem located directly in the injected muscle. For example, botu-linum toxin and other substances can be injected directly into hyperexcitable muscles to control certain types of muscle spasms or spasticity (see Chapter 13).7,78 Alternatively, intramuscular injection can be used as a method for a relatively steady, prolonged release of the drug into the systemic circulation to control conditions such as psychosis,2 or to administer certain vaccines. 

Aktas, M., H. P. Lefebvre, P. L. Toutain, and J. P. Braun. 1995. Disposition of creatine kinase activity in dog plasma following intravenous and intramuscular injection of skeletal muscle homogenates. Journal of Veterinary Pharmacology and Therapeutics 18 1-6. Aktas, M., P. Vinclair, H. P. Lefebvre, P. L. Toutain, and J. P. Braun. 1995. In vivo quantification of muscle damage in dogs after intramuscular administration of drugs. British Veterinary Journal 151 189-196. 

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