Muscle cramps with hemodialysis

Sidhom OA, Odeh YK, Krumlovsky FA, Budris WA, Wang Z, Pospisil PA, Atkinson AJ Jr. Low dose prazosin in patients with muscle cramps during hemodialysis. Clin Pharmacol Ther 1994 56 445-51. 

Pathophysiology Muscle cramps can occur with up to 20% of dialysis sessions.48 The cause is often related to excessive ultrafiltration, which causes hypoperfusion of the muscles. Other contributing factors to the development of muscle cramps include hypotension and electrolyte and acid-base imbalances that occur during hemodialysis sessions. 

Quinine Sulfate. Basic quinine sulfate. C Hj,. N40,S mol wt 746.93. C 64.32%, H 6.75%, N 7.50%, O 17.14%. S 4.29%. 2CmHMN.0j.HiS04. Quinine snlfaw crystallizes with 8 mols water (16.17% HjO), but it loses one mol very rapidly even at 20. On exposure to air at ordinary temp it gradually loses 5 more mols of water. Double-blind study in prevention of hemodialysis-induced muscle cramps D. M. Kaji et at., Lancet 2, 66 (1976) in prevention of nocturnal recumbency muscle cramps K. Jones, C. M. Castle-den, Age Ageing 12, 155 (1983). 

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