Muscarinic binding sites

Ator NA, Grant KA, Purdy RH, et al Drug discrimination analysis of endogenous neuroactive steroids in rats. Eur J Pharmacol 241 237-243, 1993 Aubert 1, Araujo DM, Cecyre D, et al Comparative alterations of nicotinic and muscarinic binding sites in Alzheimer s and Parkinson s diseases. J Neurochem 58 529-541, 1992... 

With regards to the effects of antipsychotic medications on muscarinic and nAChR in the brain, only olanzapine resulted in a temporary increase of muscarinic binding sites in a long-term study of different typical and atypical antipsychotics (Terry et al., 2006). This result is in accordance with in vitro (Bymaster et al., 1996 Schotte et al., 1996) and in vivo (Raedler et al., 2000) studies showing that olanzapine has considerable affinity to mAChRs. 

Apparent afiBnities (pKj values) for (R)- and (S)-dimethindene at muscarinic binding sites in various tissues and cell lines... 

Muscarinic binding sites were labelled using [ HJN-methylscopolamine. Hill coefiBcients of the competition curves were not significantly different fi"om unity (P>0.05). 

Hirano T, Dinger B, Yoshizaki K, Gonzalez C, Fidone S. Nicotinic versus muscarinic binding sites in cat and rabbit carotid bodies. Biol Signals 1992 1(3) 143-149. 

Jakubic, J., Bacakova, L., Lisd, V., El-Fakahany, E. E., and Tucek, S. (1996). Activation of muscarinic acetylcholine receptors via their allosteric binding sites. Proc. Natl. Acad. Sci. USA 93 8705-8709. 

Table II. Binding Constants for (+)-Anatoxin-a and Related Molecules at Nicotinic and Muscarinic Receptor Sites...

Ellis J. Allosteric binding sites on muscarinic receptors. Drug Dev Res 1997 40 193-204. 

Dunlap J, Brown JH. Heterogeneity of binding sites on cardiac muscarinic receptors induced by the neuromuscular blocking agents gallamine and pancuronium. Mol Pharmacol 1983 24 15-22. 

Neurotransmission in autonomic ganglia is more complex than depolarization mediated by a single transmitter 190 Muscarinic receptors are widely distributed at postsynaptic parasympathetic effector sites 190 Stimulation of the motoneuron releases acetylcholine onto the muscle endplate and results in contraction of the muscle fiber 191 Competitive blocking agents cause muscle paralysis by preventing access of acetylcholine to its binding site on the receptor 191... 

Batra S (1990) Interaction of antiestrogens with binding sites for muscarinic cholinergic drugs and calcium channel blockers in cell membranes. Cancer Chemother Pharmacol 26 310-312... 

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