Munich Information Center for Protein Sequences

Protein information resource (Barker et al., 1999) was established in 1984 by the National Biomedical Research Foundation (NBRF) as a successor to the original NBRF Protein Sequence Database, developed over 20 years by the late Margaret O. Dayhoff and published as the Atlas of Protein Sequence and Structure (Dayhoff et al., 1965 Dayhoff, 1979). Since 1988 the database has been maintained by PIR-Intemational, a collaboration between the NBRF, the Munich Information Center for Protein Sequences (MIPS), and the Japan International Protein Information Database (JIPID). 

There are different classes of protein sequence databases. Primary and secondary databases are used to address different aspects of sequence analysis. Composite databases amalgamate a variety of different primary sources to facilitate sequence searching efficiently. The primary structure (amino acid sequence) of a protein is stored in primary databases as linear alphabets that represent the constituent residues. The secondary structure of a protein corresponding to region of local regularity (e.g., a-helices, /1-strands, and turns), which in sequence alignments are often apparent as conserved motifs, is stored in secondary databases as patterns. The tertiary structure of a protein derived from the packing of its secondary structural elements which may form folds and domains is stored in structure databases as sets of atomic coordinates. Some of the most important protein sequence databases are PIR (Protein Information Resource), SWISS-PROT (at EBI and ExPASy), MIPS (Munich Information Center for Protein Sequences), JIPID (Japanese International Protein Sequence Database), and TrEMBL (at EBI). ... 

The Munich Information Center for Protein Sequences (MIPS) (Mewes et al., 2000) collects and processes sequence data for the PIR-International Protein Sequence Database project. Access to the database is provided through its Web server, http //www.mips.biochem.mpg.de/. The implementation of PrIAn (Protein Input and Annotation) data input has greatly increased database entries of PIR-International. 

The Munich Information Center for Protein Sequences [Mewes et al. 2004] is a group established within the Max Planck Institute for Biochemistry that has been developing methods for proteomic and metabolic analysis of gene expression data since the early 1990s. 

The Munich Information Center for Protein Sequences Website was used to obtain this information. The prediction of transmembrane domains at this site is based on Klein et alP and Goffeau et alP ... 

MIPSPlantsDB Munich Information Center for Protein Sequences Plants... 

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