Multitarget drug

Bender, A., Jenkins, J. L., Click, M., et al. 2006. "Bayes affinity fingerprints" improve retrieval rates in virtual screening and define orthogonal bioactivity space When are multitarget drugs a feasible concept /. Chem. Inf. Model. 46 2445-2456. 

Carrascosa, M.C., Massaguer, O.L., and Mestres, J. (2012) PharmaTrek a semantic web explorer for open innovation in multitarget drug discovery. Mol. Inform., 31, 537-541. 

Jenwitheesuk, E., Horst, J.A., Rivas, KL., Van Voorhis, W.C. and Samudrala, R. (2008) Novel paradigms for drug discovery computational multitarget screening. Trends in Pharmacological Sciences, 29, 62-71. 

Multitarget forensic applications of HPLC for other drug classes are also available in the literature. Josefsson et al. [77] applied HPLC-MS-MS to the determination of 19 neuroleptics and their major metabolites in human tissues and body fluids. Optimal separation was achieved using a cyano column within a 9 min gradient run. Detection was curried out in SRM reaching LQDs down to the lower ng/mL level, although more than a 10-fold difference in signal response was observed between analytes. The method was subjected to partial validation only. 

J Trias, Z Yuan. Mining bacterial cell wall biosynthesis with new tools multitarget screens. Drug Res Updates 2 358-362, 1999. 

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