Multitarget bioactivities

These pleiotropic multitarget bioactivities are not spedflc, but are nevertheless effective, and this is critical in an ecological context. Compounds with pleiotropic properties have the advantage that they can attack any enemy that is encormtered by a plant, be it a herbivore or a bacterium, fungus, or vims. These classes of compounds are seldom unique constituents quite often plants produce a mixture of secondary metabolites, often both phenolics and terpenoids, and thus exhibit both covalent and noncovalent interactions. These activities are probably not only additive but synergistic [10,25]. 

Bender, A., Jenkins, J. L., Click, M., et al. 2006. "Bayes affinity fingerprints" improve retrieval rates in virtual screening and define orthogonal bioactivity space When are multitarget drugs a feasible concept /. Chem. Inf. Model. 46 2445-2456. 

Wassermann AM, Dimova D, Bajorath J. Comprehensive analysis of single- and multitarget activity cliffs formed by currently available bioactive compounds. Chem Biol Drug Des 2011 78 224-228. 

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