Multistep reactions, multicomponent systems

Sanecki P (2001) A numerical modelling of voltammetric reduction of substituted iodoben-zenes reaction series. A relationship between reductions in the consecutive-mode multistep system and a multicomponent system. Determination of the potential variation of the elementary charge transfer coefficient. Comput Chem 25 521-539... 

The combination of the two approaches that have obvious advantages therefore presents an attractive reaction design with added value in the inventions and optimizations of existing processes. We hereby give an overview of current achievements in this field. However, there is a rather limited number of published data on strictly defined multicomponent reactions in which aU the reactants are added at once to the reaction mixture, due to the technical characteristics of the systems (e.g. number of inlets) or the possible complications due to side reactions such reactions are conducted in a multistep mode or employ preformed intermediates. These reactions are also taken into account on the condition that the process is conducted continuously without purification of the intermediates and that the final product contains scaffolds originating from three or more starting molecules. 

The original preparations of the bicyclo[3.3.0]system were multistep processes and not very efficient in terms of overall yield ( 15%). The initial publication by Weiss and Edwards, while comparable in yield to the previous reports, the efficiency of a multicomponent, single-step process made this variation more attractive. The initial reaction conditions focused on neutral to slightly acidic conditions, which allowed the intermediate tetra-ester 11 to precipitate as the major product from a mixture containing side products 15 and 16. 

---