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Multistage theory of carcinogenesis

Doll, R. (2004) Commentary the age distribution of cancer and a multistage theory of carcinogenesis. International Journal of Epidemiology. 33,1183-1184. [Pg.322]

The multistage theory of carcinogenesis predicts that cancer risk is dependent upon the dose rate and duration of exposure, but not necessarily leading to a relationship with total dose, the product of rate and duration. Whittemore and Keller (45), Whittemore (46), and Day and Brown (47) discuss these multistage theories and rndicate that the risk of cancer is likely to be the product of two different functions of dose rate and duration. In... [Pg.75]

Therefore, the multistage theory of carcinogenesis predicts another level of complexity in extrapolating cancer risk from one exposure situation to another, since a limited duration (e.g. 10 years) of exposure to the same dose rate will not necessarily produce the same excess cancer risk in two otherwise identical individuals whose exposure period is during different ages of their life. [Pg.76]

See other pages where Multistage theory of carcinogenesis is mentioned: [Pg.311]    [Pg.136]    [Pg.311]    [Pg.136]    [Pg.271]    [Pg.63]    [Pg.473]    [Pg.79]    [Pg.183]    [Pg.438]    [Pg.484]   
See also in sourсe #XX -- [ Pg.149 , Pg.153 ]



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