Multispecificity

James LC, Roversi P, Tawfik DS Antibody multispecificity mediated by conformational diversity. Science 2003 299 1362-1367. 

Heijn, M., Oude Elferink, R. and Jansen, P. (1992). ATP-dependent multispecific organic anion transport system in rat erythrocyte membrane vesicles. Am. J. Physiol. 262, 104-110. 

C. C. Paulusma, R. P. Oude Elferink et al. Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA, J. Clin. Invest. 1998, 101, 1310-1319... 

Yabuuchi, H., et al. Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-depen-dent transport of organic cations. J. 

Endou. The multispecific organic anion transporter (OAT) family. 

Sekine, T., et al. Expression cloning and characterization of a novel multispecific organic anion transporter. J. Biol. Chem. 1997, 272, 18526-18529. 

Bossuyt, X., M. Muller, and P. J. Meier. Multispecific amphipathic substrate transport by an organic anion transporter of human liver. J. Hepatol. 1996, 25, 733-738. 

Williams, G. C., et al. Direct Evidence that Saquinavir Is Transported by Multidrag Resistance-Associated Protein (MRP1) and Canalicular Multispecific Organic Anion Transporter (MRP2). Antimicrob. Agents Chemother. 2002, 46, 3456-3462. 

Gotoh, Y., et al. Involvement of an organic anion transporter (canalicular multispecific organic anion... 

Zimmerli, B., J. Vaiantinas, and P. J. Meier. Multispecificity of Na+-dependent taurocholate uptake in basolateral (sinusoidal) rat liver plasma membrane vesicles. J. Pharmacol. Exp. Ther. 1989, 250, 301-318. 

Yamazaki, M., Suzuki, H., Hanano, M., Tokui, T., Komai, T., Sugiyama, Y., Na(+)-independent multispecific anion transporter mediates active transport of pravastatin into rat liver, Am. J. Physiol. 1993, 264, G36-G44. 

Bruhl, B., Eckhardt, U., Follmann, W., Honscha, W., Horz, J. A., Muller, N., Nickau, L., Ottaliah-Kolac, M., Platte, H. D., Schenk, A., Schuh, K., Schulz, K., Schulz, S., What we have learned about bumeta-nide and the concept of multispecific bile acid/drug transporters from the liver, J. Hepatol. 1996, 24 (Suppl. 1), 42-46. 

Noe, B., Hagenbuch, B., Stieger, B., Meier, P. J., Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain, Proc. Natl. Acad. Sci. USA 1997, 94, 10346-10350. 

Sekine, T., Cha, S. H., Tsuda, M., Apiwattanakul, N., Nakajima, N., Kanai, Y., Endou, H., Identification of multispecific organic anion transporter 2 expressed predominantly in the liver, FEES Lett. 1998, 429, 179-182. 

Kawakami, M., Kagotani, K., Okumura, K., Akiyama, S., Kuwano, M., A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation, Cancer Res. 1996, 56, 4124-4129. 

Ni inuma, K., Nishigaki, R., Sugiyama Y., Biliary excretion of pravastatin in rats contribution of the excretion pathway mediated by canalicular multispecific organic anion transporter, Drug Metab. Dispos. 1997, 25, 1123-1129. 

Hosoyamada M, Sekine T, Kanai Y, Endou H. Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney. Am... 

Sekine T, Cha SH, Endou H. The multispecific organic anion transporter (OAT) family. Pfliigers Arch 2000 440(3) 337—350. 

Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH et al. Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem 1999 274(19) 13675-13680. 

Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK et al. Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. J Biol Chem 2000 ... 

Ito K, Suzuki H, Hirohashi T, Kume K, Shimizu T, Sugiyama Y. Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR. Am J Physiol 1997 272(1 Pt 1) G16-G22. 

Paulusma CC, Kool M, Bosma PJ, Scheffer GL, ter Borg F, Scheper RJ et al. A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome. Hepatology 1997 25(6) 1539— 1542. 

Uchiumi T, Hinoshita E, Haga S, Nakamura T, Tanaka T, Toh S et al. Isolation of a novel human canalicular multispecific organic anion transporter, cMOAT2/MRP3, and its expression in cisplatin-resistant cancer cells with decreased ATP-dependent drug transport. Biochem Biophys Res Commun 1998 252(1)703-110. 

Zeng H, Bain LJ, Belinsky MG, Kruh GD. Expression of multidrug resistance protein-3 (multispecific organic anion transporter-D) in human embryonic kid-... 

Toh S, Wada M, Uchiumi T, Inokuchi A, Makino Y, Horie Y et al. Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/ cMOAT) and mutations in the ATP-bind-ing-cassette region in Dubin-Johnson syndrome. Am J Hum Genet 1999 64(3)739-746. 

Wada M, Toh S, Taniguchi K, Nakamura T, Uchiumi T, Kohno K et al. Mutations in the canalicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia I I/Dubin-Johnson syndrome. Hum Mol Genet 1998 7(2) 203-207. 

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