Multiplicative signal correction analysis

H. Martens, J.P. Nielsen and S.B. Engelsen, Light scattering and light absorbance separated by extended multiplicative signal correction. Application to near-infrared transmission analysis of powder mixtures, Anal Chem., 75, 394 (2003). 

Melting point Mass spectrometry Multiplicative signal correction Microspecular reflectance Molecular weight Neutron activation analysis Nickel oxide... 

Kohler A, Zimonja M, Segman V, Martens H. Standard normal variate, multiplicative signal correction and extended multiplicative signal correction preprocessing in biospectroscopy. In Brown SD, Tauler R, Walczak B, editors. Comprehensive chemometrics chemical and biochemical data analysis, vol. 2. Amsterdam Elsevier Ltd. 2009. p. 211-27 [chapter 2.09]. 

All samples were ground to a specific mesh size (either 250 or 100 pm). To expand the calibration range, samples were diluted with the primary filler or overdosed with ascorbic acid. Prior to analysis, three preprocessing methods were evaluated multiplicative scatter correction (MSC), signal scaling, and first derivative. In this study, first-derivative spectra provided the best calibration results. 

Contributions from molecular ions are typically more difficult to correct quantitatively because there may be many molecular ions important over a short mass range the molecular ion intensity varies, depending on the sample matrix and the intensities may vary over time more dramatically than elemental ion signals. Multivariant methods including multiple linear regression [150,151], principal component analysis [152], and multicomponent analysis [153] have been used. Improvements in detection limits by up to two orders of magnitude... 

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