Multiple-dosing input systems and steady-state kinetics

2 Multiple-dosing input systems and steady-state kinetics. 

Zero-order input and one-compartment disposition (I0D1). The simplest case for achieving a drug plasma concentration between the MEC and MTC is to use a zero-order input. In Fig. 1.17, the six time points show time as measured in half-lives. At 3.3 half-lives, Cp is at approximately 90 percent of its true steady-state value at 5 half-lives, Cp is at approximately 96 percent of its true steady-state value. 

Multiple instantaneous input and one-compartment disposition (IBD1). In 

For multiple intravenous bolus doses, Cp in the nth dosing period is 

As Schoenwald28 points out, the MDF is quite mobile in its application and can be applied to obtain two important concentrations in the design of controlled release delivery systems—Cp max and Cp min. Under multiple-dosing intravenous bolus input, applying MDF to Cp max and Cp mgives Eqs. (1.46) and (1.47)  

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