Multiparametric monitoring

Dransfeld C-L, Alborzinia H, Woelfl S, Mahlknecht U (2010) Continuous multiparametric monitoring of cell metabolism in response to transient overexpression of the sirtuin deacetylase SIRT3. Clin Epigenet 1 55-60... 

Finally, the use of PAT should not be limited to existing processes and products but is especially attractive in the R D and scale-up of new processes and products. PAT is especially effective in scale-up. As PAT involves consideration of all monitored variables and not only an empirical selection of some of those variables, and since in-process monitoring techniques are normally multiparametric (e.g., near-infrared spectra of a whole sample), they will be more suited to capture scale effects present in the sample s matrix that show up clearly in a consolidated multivariate analysis of quality and operating variables, thus helping the skillful engineer or scientist to pinpoint and solve scale-up problems thus resulting in a much faster process prototyping and scale-up. 

A. Ayala, L.O. Leal, L. Ferrer, V. Cerda, Multiparametric automated system for sulfate, nitrite and nitrate monitoring in drinking water and wastewater based on sequential injection analysis, Microchem. J. 100 (2012) 55-60. 

Weltin, A., Enderle, B., Kieninger, J., Urban, G.A., 2014. Multiparametric, flexible microsensor platform for metabohc monitoring in vivo. Sensors Journal, IEEE 14 (10), 3345-3351. 

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